| Hilton Head Island to Effingham (Illinois) | 648.41 mi (1,043.51 km) |
| Hilton Head Island to Eggertsville (New York) | 752.12 mi (1,210.41 km) |
| Hilton Head Island to Egypt Lake-Leto (Florida) | 306.76 mi (493.68 km) |
| Hilton Head Island to El Cajon (California) | 2,100.17 mi (3,379.90 km) |
| Hilton Head Island to El Campo (Texas) | 944.15 mi (1,519.47 km) |
| Hilton Head Island to El Centro (California) | 2,019.89 mi (3,250.70 km) |
| Hilton Head Island to El Cerrito (California) | 2,363.59 mi (3,803.83 km) |
| Hilton Head Island to El Dorado (Arkansas) | 695.94 mi (1,120.01 km) |
| Hilton Head Island to El Dorado (Kansas) | 989.61 mi (1,592.62 km) |
| Hilton Head Island to El Dorado Hills (California) | 2,293.62 mi (3,691.23 km) |
| Hilton Head Island to El Mirage (Arizona) | 1,827.55 mi (2,941.16 km) |
| Hilton Head Island to El Monte (California) | 2,149.00 mi (3,458.48 km) |
| Hilton Head Island to El Paso (Texas) | 1,501.00 mi (2,415.62 km) |
| Hilton Head Island to El Paso de Robles (California) | 2,284.94 mi (3,677.25 km) |
| Hilton Head Island to El Reno (Oklahoma) | 1,013.06 mi (1,630.37 km) |
