| Hilton Head Island to Des Plaines (Illinois) | 785.38 mi (1,263.95 km) |
| Hilton Head Island to Desert Hot Springs (California) | 2,065.49 mi (3,324.09 km) |
| Hilton Head Island to DeSoto (Texas) | 939.60 mi (1,512.14 km) |
| Hilton Head Island to Destin (Florida) | 359.71 mi (578.90 km) |
| Hilton Head Island to Destrehan (Louisiana) | 589.34 mi (948.45 km) |
| Hilton Head Island to Detroit (Michigan) | 716.01 mi (1,152.31 km) |
| Hilton Head Island to Diamond Bar (California) | 2,137.54 mi (3,440.04 km) |
| Hilton Head Island to Diamond Springs (California) | 2,282.28 mi (3,672.98 km) |
| Hilton Head Island to Dickinson (North Dakota) | 1,543.13 mi (2,483.42 km) |
| Hilton Head Island to Dickinson (Texas) | 869.06 mi (1,398.62 km) |
| Hilton Head Island to Dickson (Tennessee) | 463.34 mi (745.68 km) |
| Hilton Head Island to Difficult Run (Virginia) | 501.55 mi (807.17 km) |
| Hilton Head Island to Dinuba (California) | 2,209.80 mi (3,556.33 km) |
| Hilton Head Island to Discovery Bay (California) | 2,325.34 mi (3,742.27 km) |
| Hilton Head Island to Dix Hills (New York) | 723.04 mi (1,163.61 km) |
