| Hilton Head Island to Shoreham-by-Sea | 4,138.92 mi (6,660.96 km) |
| Hilton Head Island to Shotley Bridge | 4,009.25 mi (6,452.26 km) |
| Hilton Head Island to Shrewsbury | 4,004.91 mi (6,445.29 km) |
| Hilton Head Island to Sidcup | 4,143.88 mi (6,668.92 km) |
| Hilton Head Island to Sidmouth | 4,015.94 mi (6,463.03 km) |
| Hilton Head Island to Sileby | 4,071.75 mi (6,552.85 km) |
| Hilton Head Island to Sittingbourne | 4,171.97 mi (6,714.13 km) |
| Hilton Head Island to Skegness | 4,123.39 mi (6,635.95 km) |
| Hilton Head Island to Skelmersdale | 3,991.75 mi (6,424.10 km) |
| Hilton Head Island to Skipton | 4,016.14 mi (6,463.35 km) |
| Hilton Head Island to Sleaford | 4,095.47 mi (6,591.01 km) |
| Hilton Head Island to Slough | 4,113.70 mi (6,620.36 km) |
| Hilton Head Island to Small Heath | 4,045.51 mi (6,510.61 km) |
| Hilton Head Island to Smethwick | 4,040.34 mi (6,502.30 km) |
| Hilton Head Island to Snaresbrook | 4,137.33 mi (6,658.40 km) |
