| Highlands Ranch to Storm Lake (Iowa) | 551.82 mi (888.07 km) |
| Highlands Ranch to Storrs (Connecticut) | 1,711.30 mi (2,754.07 km) |
| Highlands Ranch to Stoughton (Wisconsin) | 849.54 mi (1,367.21 km) |
| Highlands Ranch to Stow (Ohio) | 1,240.50 mi (1,996.39 km) |
| Highlands Ranch to Streamwood (Illinois) | 893.57 mi (1,438.06 km) |
| Highlands Ranch to Streator (Illinois) | 855.89 mi (1,377.42 km) |
| Highlands Ranch to Streetsboro (Ohio) | 1,244.92 mi (2,003.51 km) |
| Highlands Ranch to Strongsville (Ohio) | 1,219.53 mi (1,962.65 km) |
| Highlands Ranch to Stuart (Florida) | 1,653.93 mi (2,661.75 km) |
| Highlands Ranch to Stuarts Draft (Virginia) | 1,396.05 mi (2,246.72 km) |
| Highlands Ranch to Sturgis (Michigan) | 1,034.14 mi (1,664.28 km) |
| Highlands Ranch to Suamico (Wisconsin) | 933.17 mi (1,501.80 km) |
| Highlands Ranch to Sudley (Virginia) | 1,467.02 mi (2,360.95 km) |
| Highlands Ranch to Suffern (New York) | 1,619.01 mi (2,605.54 km) |
| Highlands Ranch to Suffolk (Virginia) | 1,546.06 mi (2,488.15 km) |
