| Highlands Ranch to Southern Pines (North Carolina) | 1,430.59 mi (2,302.31 km) |
| Highlands Ranch to Southfield (Michigan) | 1,146.66 mi (1,845.37 km) |
| Highlands Ranch to Southgate (Michigan) | 1,148.67 mi (1,848.61 km) |
| Highlands Ranch to Southlake (Texas) | 629.60 mi (1,013.25 km) |
| Highlands Ranch to Spanaway (Washington) | 1,017.50 mi (1,637.51 km) |
| Highlands Ranch to Spanish Fork (Utah) | 356.00 mi (572.93 km) |
| Highlands Ranch to Spanish Lake (Missouri) | 791.68 mi (1,274.09 km) |
| Highlands Ranch to Spanish Springs (Nevada) | 781.69 mi (1,258.00 km) |
| Highlands Ranch to Sparks (Nevada) | 784.60 mi (1,262.69 km) |
| Highlands Ranch to Spartanburg (South Carolina) | 1,302.82 mi (2,096.69 km) |
| Highlands Ranch to Spearfish (South Dakota) | 347.04 mi (558.50 km) |
| Highlands Ranch to Speedway (Indiana) | 994.10 mi (1,599.86 km) |
| Highlands Ranch to Spencer (Iowa) | 566.40 mi (911.53 km) |
| Highlands Ranch to Spokane (Washington) | 837.12 mi (1,347.21 km) |
| Highlands Ranch to Spokane Valley (Washington) | 829.63 mi (1,335.17 km) |
