| Highlands Ranch to Silver Firs (Washington) | 1,029.28 mi (1,656.46 km) |
| Highlands Ranch to Silver Spring (Maryland) | 1,489.43 mi (2,397.01 km) |
| Highlands Ranch to Silver Springs Shores (Florida) | 1,488.69 mi (2,395.81 km) |
| Highlands Ranch to Silverdale (Washington) | 1,045.23 mi (1,682.14 km) |
| Highlands Ranch to Silverton (Oregon) | 982.99 mi (1,581.96 km) |
| Highlands Ranch to Simi Valley (California) | 842.76 mi (1,356.29 km) |
| Highlands Ranch to Simpsonville (South Carolina) | 1,290.69 mi (2,077.16 km) |
| Highlands Ranch to Sioux City (Iowa) | 491.37 mi (790.78 km) |
| Highlands Ranch to Sioux Falls (South Dakota) | 507.43 mi (816.63 km) |
| Highlands Ranch to Skokie (Illinois) | 916.05 mi (1,474.23 km) |
| Highlands Ranch to Sleepy Hollow (New York) | 1,633.13 mi (2,628.27 km) |
| Highlands Ranch to Slidell (Louisiana) | 1,069.49 mi (1,721.18 km) |
| Highlands Ranch to Smithfield (North Carolina) | 1,479.37 mi (2,380.82 km) |
| Highlands Ranch to Smithfield (Utah) | 392.41 mi (631.53 km) |
| Highlands Ranch to Smithville (Missouri) | 554.31 mi (892.08 km) |
