| Highlands Ranch to Seymour (Tennessee) | 1,183.36 mi (1,904.44 km) |
| Highlands Ranch to Shady Hills (Florida) | 1,491.35 mi (2,400.10 km) |
| Highlands Ranch to Shafter (California) | 827.78 mi (1,332.19 km) |
| Highlands Ranch to Shaker Heights (Ohio) | 1,233.79 mi (1,985.59 km) |
| Highlands Ranch to Shakopee (Minnesota) | 689.86 mi (1,110.22 km) |
| Highlands Ranch to Sharon (Pennsylvania) | 1,288.84 mi (2,074.19 km) |
| Highlands Ranch to Sharonville (Ohio) | 1,095.47 mi (1,762.99 km) |
| Highlands Ranch to Shasta Lake (California) | 921.65 mi (1,483.25 km) |
| Highlands Ranch to Shawnee (Kansas) | 544.48 mi (876.26 km) |
| Highlands Ranch to Shawnee (Oklahoma) | 525.62 mi (845.90 km) |
| Highlands Ranch to Sheboygan (Wisconsin) | 934.16 mi (1,503.39 km) |
| Highlands Ranch to Shelby (North Carolina) | 1,314.61 mi (2,115.67 km) |
| Highlands Ranch to Shelbyville (Indiana) | 1,020.66 mi (1,642.59 km) |
| Highlands Ranch to Shelbyville (Kentucky) | 1,063.77 mi (1,711.97 km) |
| Highlands Ranch to Shelbyville (Tennessee) | 1,050.45 mi (1,690.54 km) |
