| Highlands Ranch to Scottsboro (Alabama) | 1,093.90 mi (1,760.46 km) |
| Highlands Ranch to Scottsdale (Arizona) | 556.26 mi (895.22 km) |
| Highlands Ranch to Scranton (Pennsylvania) | 1,538.32 mi (2,475.69 km) |
| Highlands Ranch to Seabrook (Maryland) | 1,498.72 mi (2,411.96 km) |
| Highlands Ranch to Seabrook (Texas) | 890.16 mi (1,432.57 km) |
| Highlands Ranch to Seaford (New York) | 1,656.48 mi (2,665.84 km) |
| Highlands Ranch to Seagoville (Texas) | 668.56 mi (1,075.94 km) |
| Highlands Ranch to Seal Beach (California) | 827.83 mi (1,332.27 km) |
| Highlands Ranch to Searcy (Arkansas) | 783.98 mi (1,261.70 km) |
| Highlands Ranch to Seaside (California) | 936.77 mi (1,507.59 km) |
| Highlands Ranch to SeaTac (Washington) | 1,022.41 mi (1,645.42 km) |
| Highlands Ranch to Seattle (Washington) | 1,028.89 mi (1,655.83 km) |
| Highlands Ranch to Sebastian (Florida) | 1,617.97 mi (2,603.87 km) |
| Highlands Ranch to Sebring (Florida) | 1,583.29 mi (2,548.06 km) |
| Highlands Ranch to Secaucus (New Jersey) | 1,625.68 mi (2,616.27 km) |
