| Highlands Ranch to Indianola (Iowa) | 612.23 mi (985.29 km) |
| Highlands Ranch to Indio (California) | 741.38 mi (1,193.13 km) |
| Highlands Ranch to Inglewood (California) | 833.69 mi (1,341.70 km) |
| Highlands Ranch to Inkster (Michigan) | 1,143.32 mi (1,840.00 km) |
| Highlands Ranch to Inver Grove Heights (Minnesota) | 709.65 mi (1,142.07 km) |
| Highlands Ranch to Inwood (New York) | 1,643.47 mi (2,644.92 km) |
| Highlands Ranch to Iona (Florida) | 1,600.68 mi (2,576.04 km) |
| Highlands Ranch to Ionia (Michigan) | 1,057.69 mi (1,702.19 km) |
| Highlands Ranch to Iowa City (Iowa) | 719.28 mi (1,157.57 km) |
| Highlands Ranch to Irmo (South Carolina) | 1,363.09 mi (2,193.67 km) |
| Highlands Ranch to Irondale (Alabama) | 1,095.08 mi (1,762.35 km) |
| Highlands Ranch to Ironton (Ohio) | 1,195.37 mi (1,923.77 km) |
| Highlands Ranch to Irvine (California) | 816.39 mi (1,313.86 km) |
| Highlands Ranch to Irving (Texas) | 641.51 mi (1,032.41 km) |
| Highlands Ranch to Isabela (Puerto Rico) | 2,684.95 mi (4,321.01 km) |
