| Highlands Ranch to Enterprise (Nevada) | 610.55 mi (982.58 km) |
| Highlands Ranch to Enumclaw (Washington) | 1,002.09 mi (1,612.71 km) |
| Highlands Ranch to Ephrata (Pennsylvania) | 1,520.81 mi (2,447.50 km) |
| Highlands Ranch to Erie (Colorado) | 34.64 mi (55.74 km) |
| Highlands Ranch to Erie (Pennsylvania) | 1,309.01 mi (2,106.65 km) |
| Highlands Ranch to Erlanger (Kentucky) | 1,088.55 mi (1,751.85 km) |
| Highlands Ranch to Escanaba (Michigan) | 1,001.86 mi (1,612.34 km) |
| Highlands Ranch to Escondido (California) | 804.85 mi (1,295.28 km) |
| Highlands Ranch to Española (New Mexico) | 251.66 mi (405.00 km) |
| Highlands Ranch to Essex (Maryland) | 1,516.20 mi (2,440.08 km) |
| Highlands Ranch to Essex Junction (Vermont) | 1,659.57 mi (2,670.82 km) |
| Highlands Ranch to Estelle (Louisiana) | 1,075.61 mi (1,731.03 km) |
| Highlands Ranch to Estero (Florida) | 1,612.42 mi (2,594.94 km) |
| Highlands Ranch to Euclid (Ohio) | 1,235.19 mi (1,987.84 km) |
| Highlands Ranch to Eufaula (Alabama) | 1,226.83 mi (1,974.40 km) |
