| Hermiston to Southern Pines (North Carolina) | 2,193.74 mi (3,530.49 km) |
| Hermiston to Southfield (Michigan) | 1,785.43 mi (2,873.37 km) |
| Hermiston to Southgate (Michigan) | 1,794.54 mi (2,888.03 km) |
| Hermiston to Southlake (Texas) | 1,470.98 mi (2,367.31 km) |
| Hermiston to Spanaway (Washington) | 173.02 mi (278.46 km) |
| Hermiston to Spanish Fork (Utah) | 552.41 mi (889.01 km) |
| Hermiston to Spanish Lake (Missouri) | 1,553.35 mi (2,499.87 km) |
| Hermiston to Spanish Springs (Nevada) | 427.15 mi (687.43 km) |
| Hermiston to Sparks (Nevada) | 433.01 mi (696.86 km) |
| Hermiston to Spartanburg (South Carolina) | 2,082.33 mi (3,351.18 km) |
| Hermiston to Spearfish (South Dakota) | 758.13 mi (1,220.09 km) |
| Hermiston to Speedway (Indiana) | 1,712.43 mi (2,755.89 km) |
| Hermiston to Spencer (Iowa) | 1,199.12 mi (1,929.80 km) |
| Hermiston to Spokane (Washington) | 154.12 mi (248.03 km) |
| Hermiston to Spokane Valley (Washington) | 159.41 mi (256.54 km) |
