| Guaynabo to Southern Pines (North Carolina) | 1,418.35 mi (2,282.61 km) |
| Guaynabo to Southfield (Michigan) | 1,944.51 mi (3,129.38 km) |
| Guaynabo to Southgate (Michigan) | 1,927.74 mi (3,102.41 km) |
| Guaynabo to Southlake (Texas) | 2,167.36 mi (3,488.03 km) |
| Guaynabo to Spanaway (Washington) | 3,723.35 mi (5,992.15 km) |
| Guaynabo to Spanish Fork (Utah) | 3,083.74 mi (4,962.79 km) |
| Guaynabo to Spanish Lake (Missouri) | 2,018.47 mi (3,248.42 km) |
| Guaynabo to Spanish Springs (Nevada) | 3,493.38 mi (5,622.06 km) |
| Guaynabo to Sparks (Nevada) | 3,494.98 mi (5,624.62 km) |
| Guaynabo to Spartanburg (South Carolina) | 1,499.85 mi (2,413.77 km) |
| Guaynabo to Spearfish (South Dakota) | 2,821.28 mi (4,540.40 km) |
| Guaynabo to Speedway (Indiana) | 1,905.06 mi (3,065.89 km) |
| Guaynabo to Spencer (Iowa) | 2,405.48 mi (3,871.25 km) |
| Guaynabo to Spokane (Washington) | 3,507.33 mi (5,644.50 km) |
| Guaynabo to Spokane Valley (Washington) | 3,498.41 mi (5,630.15 km) |
