| Guaynabo to Enterprise (Nevada) | 3,215.47 mi (5,174.80 km) |
| Guaynabo to Enumclaw (Washington) | 3,705.00 mi (5,962.61 km) |
| Guaynabo to Ephrata (Pennsylvania) | 1,620.96 mi (2,608.68 km) |
| Guaynabo to Erie (Colorado) | 2,751.13 mi (4,427.52 km) |
| Guaynabo to Erie (Pennsylvania) | 1,833.61 mi (2,950.91 km) |
| Guaynabo to Erlanger (Kentucky) | 1,804.53 mi (2,904.11 km) |
| Guaynabo to Escanaba (Michigan) | 2,239.47 mi (3,604.07 km) |
| Guaynabo to Escondido (California) | 3,296.25 mi (5,304.80 km) |
| Guaynabo to Española (New Mexico) | 2,715.25 mi (4,369.77 km) |
| Guaynabo to Essex (Maryland) | 1,572.08 mi (2,530.02 km) |
| Guaynabo to Essex Junction (Vermont) | 1,848.70 mi (2,975.20 km) |
| Guaynabo to Estelle (Louisiana) | 1,702.30 mi (2,739.58 km) |
| Guaynabo to Estero (Florida) | 1,144.09 mi (1,841.23 km) |
| Guaynabo to Euclid (Ohio) | 1,842.90 mi (2,965.86 km) |
| Guaynabo to Eufaula (Alabama) | 1,509.26 mi (2,428.92 km) |
