| Guayama to Enterprise (Nevada) | 3,230.92 mi (5,199.66 km) |
| Guayama to Enumclaw (Washington) | 3,725.38 mi (5,995.43 km) |
| Guayama to Ephrata (Pennsylvania) | 1,647.66 mi (2,651.66 km) |
| Guayama to Erie (Colorado) | 2,770.00 mi (4,457.88 km) |
| Guayama to Erie (Pennsylvania) | 1,859.61 mi (2,992.75 km) |
| Guayama to Erlanger (Kentucky) | 1,828.12 mi (2,942.08 km) |
| Guayama to Escanaba (Michigan) | 2,264.59 mi (3,644.50 km) |
| Guayama to Escondido (California) | 3,309.95 mi (5,326.85 km) |
| Guayama to Española (New Mexico) | 2,731.65 mi (4,396.17 km) |
| Guayama to Essex (Maryland) | 1,598.55 mi (2,572.62 km) |
| Guayama to Essex Junction (Vermont) | 1,876.47 mi (3,019.89 km) |
| Guayama to Estelle (Louisiana) | 1,717.68 mi (2,764.35 km) |
| Guayama to Estero (Florida) | 1,159.41 mi (1,865.89 km) |
| Guayama to Euclid (Ohio) | 1,868.36 mi (3,006.84 km) |
| Guayama to Eufaula (Alabama) | 1,528.41 mi (2,459.74 km) |
