| Guayama to Des Plaines (Illinois) | 2,099.47 mi (3,378.77 km) |
| Guayama to Desert Hot Springs (California) | 3,285.43 mi (5,287.38 km) |
| Guayama to DeSoto (Texas) | 2,159.14 mi (3,474.80 km) |
| Guayama to Destin (Florida) | 1,539.44 mi (2,477.49 km) |
| Guayama to Destrehan (Louisiana) | 1,735.51 mi (2,793.03 km) |
| Guayama to Detroit (Michigan) | 1,959.77 mi (3,153.94 km) |
| Guayama to Diamond Bar (California) | 3,358.29 mi (5,404.65 km) |
| Guayama to Diamond Springs (California) | 3,562.82 mi (5,733.80 km) |
| Guayama to Dickinson (North Dakota) | 2,881.49 mi (4,637.32 km) |
| Guayama to Dickinson (Texas) | 1,988.24 mi (3,199.76 km) |
| Guayama to Dickson (Tennessee) | 1,801.21 mi (2,898.77 km) |
| Guayama to Difficult Run (Virginia) | 1,595.83 mi (2,568.23 km) |
| Guayama to Dinuba (California) | 3,466.12 mi (5,578.17 km) |
| Guayama to Discovery Bay (California) | 3,597.15 mi (5,789.06 km) |
| Guayama to Dix Hills (New York) | 1,634.71 mi (2,630.81 km) |
