| Grosse Pointe Woods to Southern Pines (North Carolina) | 534.57 mi (860.30 km) |
| Grosse Pointe Woods to Southfield (Michigan) | 18.65 mi (30.01 km) |
| Grosse Pointe Woods to Southgate (Michigan) | 22.42 mi (36.08 km) |
| Grosse Pointe Woods to Southlake (Texas) | 1,015.51 mi (1,634.30 km) |
| Grosse Pointe Woods to Spanaway (Washington) | 1,944.12 mi (3,128.76 km) |
| Grosse Pointe Woods to Spanish Fork (Utah) | 1,493.95 mi (2,404.29 km) |
| Grosse Pointe Woods to Spanish Lake (Missouri) | 458.54 mi (737.95 km) |
| Grosse Pointe Woods to Spanish Springs (Nevada) | 1,910.64 mi (3,074.87 km) |
| Grosse Pointe Woods to Sparks (Nevada) | 1,914.77 mi (3,081.53 km) |
| Grosse Pointe Woods to Spartanburg (South Carolina) | 520.32 mi (837.37 km) |
| Grosse Pointe Woods to Spearfish (South Dakota) | 1,055.55 mi (1,698.75 km) |
| Grosse Pointe Woods to Speedway (Indiana) | 252.43 mi (406.25 km) |
| Grosse Pointe Woods to Spencer (Iowa) | 622.72 mi (1,002.17 km) |
| Grosse Pointe Woods to Spokane (Washington) | 1,708.99 mi (2,750.36 km) |
| Grosse Pointe Woods to Spokane Valley (Washington) | 1,699.77 mi (2,735.51 km) |
