| Grosse Pointe Woods to Seymour (Tennessee) | 455.51 mi (733.07 km) |
| Grosse Pointe Woods to Shady Hills (Florida) | 969.74 mi (1,560.65 km) |
| Grosse Pointe Woods to Shafter (California) | 1,992.53 mi (3,206.66 km) |
| Grosse Pointe Woods to Shaker Heights (Ohio) | 96.04 mi (154.57 km) |
| Grosse Pointe Woods to Shakopee (Minnesota) | 552.88 mi (889.77 km) |
| Grosse Pointe Woods to Sharon (Pennsylvania) | 148.83 mi (239.53 km) |
| Grosse Pointe Woods to Sharonville (Ohio) | 231.73 mi (372.94 km) |
| Grosse Pointe Woods to Shasta Lake (California) | 2,026.29 mi (3,261.00 km) |
| Grosse Pointe Woods to Shawnee (Kansas) | 666.13 mi (1,072.03 km) |
| Grosse Pointe Woods to Shawnee (Oklahoma) | 899.11 mi (1,446.97 km) |
| Grosse Pointe Woods to Sheboygan (Wisconsin) | 259.92 mi (418.30 km) |
| Grosse Pointe Woods to Shelby (North Carolina) | 499.08 mi (803.18 km) |
| Grosse Pointe Woods to Shelbyville (Indiana) | 250.48 mi (403.11 km) |
| Grosse Pointe Woods to Shelbyville (Kentucky) | 316.96 mi (510.10 km) |
| Grosse Pointe Woods to Shelbyville (Tennessee) | 515.83 mi (830.15 km) |
