| Grosse Pointe Woods to Olympia Heights (Florida) | 1,163.83 mi (1,873.00 km) |
| Grosse Pointe Woods to Omaha (Nebraska) | 681.16 mi (1,096.21 km) |
| Grosse Pointe Woods to On Top of the World Designated Place (Florida) | 921.70 mi (1,483.33 km) |
| Grosse Pointe Woods to Onalaska (Wisconsin) | 430.38 mi (692.64 km) |
| Grosse Pointe Woods to Oneida (New York) | 369.65 mi (594.90 km) |
| Grosse Pointe Woods to Oneonta (New York) | 399.18 mi (642.42 km) |
| Grosse Pointe Woods to Ontario (California) | 1,955.47 mi (3,147.03 km) |
| Grosse Pointe Woods to Ontario (Oregon) | 1,706.76 mi (2,746.76 km) |
| Grosse Pointe Woods to Opa-locka (Florida) | 1,152.38 mi (1,854.57 km) |
| Grosse Pointe Woods to Opelika (Alabama) | 688.83 mi (1,108.57 km) |
| Grosse Pointe Woods to Opelousas (Louisiana) | 966.90 mi (1,556.08 km) |
| Grosse Pointe Woods to Orange (California) | 1,973.98 mi (3,176.81 km) |
| Grosse Pointe Woods to Orange (Texas) | 1,042.03 mi (1,676.99 km) |
| Grosse Pointe Woods to Orange City (Florida) | 937.20 mi (1,508.28 km) |
| Grosse Pointe Woods to Orangeburg (South Carolina) | 627.73 mi (1,010.24 km) |
