| Greenville to Southern Pines (North Carolina) | 169.34 mi (272.53 km) |
| Greenville to Southfield (Michigan) | 530.15 mi (853.19 km) |
| Greenville to Southgate (Michigan) | 511.19 mi (822.68 km) |
| Greenville to Southlake (Texas) | 857.07 mi (1,379.32 km) |
| Greenville to Spanaway (Washington) | 2,225.55 mi (3,581.68 km) |
| Greenville to Spanish Fork (Utah) | 1,638.27 mi (2,636.54 km) |
| Greenville to Spanish Lake (Missouri) | 512.37 mi (824.58 km) |
| Greenville to Spanish Springs (Nevada) | 2,063.59 mi (3,321.03 km) |
| Greenville to Sparks (Nevada) | 2,066.35 mi (3,325.47 km) |
| Greenville to Spartanburg (South Carolina) | 26.02 mi (41.87 km) |
| Greenville to Spearfish (South Dakota) | 1,315.73 mi (2,117.46 km) |
| Greenville to Speedway (Indiana) | 403.51 mi (649.39 km) |
| Greenville to Spencer (Iowa) | 893.43 mi (1,437.84 km) |
| Greenville to Spokane (Washington) | 2,003.19 mi (3,223.82 km) |
| Greenville to Spokane Valley (Washington) | 1,994.14 mi (3,209.25 km) |
