| Gateway to Superior (Colorado) | 1,629.33 mi (2,622.15 km) |
| Gateway to Superior (Wisconsin) | 1,500.23 mi (2,414.38 km) |
| Gateway to Surprise (Arizona) | 1,891.70 mi (3,044.39 km) |
| Gateway to Susanville (California) | 2,410.93 mi (3,880.01 km) |
| Gateway to Sussex (Wisconsin) | 1,200.40 mi (1,931.85 km) |
| Gateway to Suwanee (Georgia) | 534.46 mi (860.14 km) |
| Gateway to Swansea (Illinois) | 955.24 mi (1,537.31 km) |
| Gateway to Sweetwater (Florida) | 101.30 mi (163.03 km) |
| Gateway to Sweetwater (Texas) | 1,191.60 mi (1,917.69 km) |
| Gateway to Sycamore (Illinois) | 1,135.38 mi (1,827.22 km) |
| Gateway to Sylacauga (Alabama) | 529.99 mi (852.94 km) |
| Gateway to Sylvania (Ohio) | 1,051.37 mi (1,692.01 km) |
| Gateway to Syosset (New York) | 1,090.52 mi (1,755.02 km) |
| Gateway to Syracuse (New York) | 1,180.18 mi (1,899.32 km) |
| Gateway to Syracuse (Utah) | 1,993.32 mi (3,207.94 km) |
