| Gateway to Southern Pines (North Carolina) | 611.04 mi (983.37 km) |
| Gateway to Southfield (Michigan) | 1,101.72 mi (1,773.05 km) |
| Gateway to Southgate (Michigan) | 1,082.77 mi (1,742.55 km) |
| Gateway to Southlake (Texas) | 1,022.13 mi (1,644.96 km) |
| Gateway to Spanaway (Washington) | 2,616.23 mi (4,210.42 km) |
| Gateway to Spanish Fork (Utah) | 1,949.06 mi (3,136.70 km) |
| Gateway to Spanish Lake (Missouri) | 975.52 mi (1,569.95 km) |
| Gateway to Spanish Springs (Nevada) | 2,351.83 mi (3,784.90 km) |
| Gateway to Sparks (Nevada) | 2,353.19 mi (3,787.09 km) |
| Gateway to Spartanburg (South Carolina) | 578.06 mi (930.29 km) |
| Gateway to Spearfish (South Dakota) | 1,741.58 mi (2,802.80 km) |
| Gateway to Speedway (Indiana) | 949.07 mi (1,527.38 km) |
| Gateway to Spencer (Iowa) | 1,370.19 mi (2,205.10 km) |
| Gateway to Spokane (Washington) | 2,412.92 mi (3,883.22 km) |
| Gateway to Spokane Valley (Washington) | 2,404.39 mi (3,869.49 km) |
