| Gateway to Santa Rosa (California) | 2,500.07 mi (4,023.47 km) |
| Gateway to Santaquin (Utah) | 1,953.56 mi (3,143.95 km) |
| Gateway to Santee (California) | 2,148.33 mi (3,457.41 km) |
| Gateway to Sapulpa (Oklahoma) | 1,066.98 mi (1,717.13 km) |
| Gateway to Saraland (Alabama) | 484.93 mi (780.41 km) |
| Gateway to Sarasota (Florida) | 71.92 mi (115.74 km) |
| Gateway to Sarasota Springs (Florida) | 67.54 mi (108.69 km) |
| Gateway to Saratoga (California) | 2,454.38 mi (3,949.94 km) |
| Gateway to Saratoga Springs (New York) | 1,224.11 mi (1,970.01 km) |
| Gateway to Saratoga Springs (Utah) | 1,968.14 mi (3,167.42 km) |
| Gateway to Sartell (Minnesota) | 1,484.36 mi (2,388.85 km) |
| Gateway to Satellite Beach (Florida) | 130.84 mi (210.57 km) |
| Gateway to Sauk Rapids (Minnesota) | 1,481.45 mi (2,384.16 km) |
| Gateway to Sault Ste. Marie (Michigan) | 1,382.63 mi (2,225.13 km) |
| Gateway to Savage (Minnesota) | 1,411.63 mi (2,271.80 km) |
