| Gainesville to Superior (Colorado) | 1,469.21 mi (2,364.47 km) |
| Gainesville to Superior (Wisconsin) | 1,286.59 mi (2,070.56 km) |
| Gainesville to Surprise (Arizona) | 1,785.16 mi (2,872.95 km) |
| Gainesville to Susanville (California) | 2,267.75 mi (3,649.59 km) |
| Gainesville to Sussex (Wisconsin) | 984.69 mi (1,584.70 km) |
| Gainesville to Suwanee (Georgia) | 318.42 mi (512.45 km) |
| Gainesville to Swansea (Illinois) | 752.07 mi (1,210.34 km) |
| Gainesville to Sweetwater (Florida) | 295.27 mi (475.19 km) |
| Gainesville to Sweetwater (Texas) | 1,084.79 mi (1,745.80 km) |
| Gainesville to Sycamore (Illinois) | 921.25 mi (1,482.61 km) |
| Gainesville to Sylacauga (Alabama) | 334.10 mi (537.68 km) |
| Gainesville to Sylvania (Ohio) | 834.64 mi (1,343.23 km) |
| Gainesville to Syosset (New York) | 915.88 mi (1,473.97 km) |
| Gainesville to Syracuse (New York) | 984.76 mi (1,584.82 km) |
| Gainesville to Syracuse (Utah) | 1,838.43 mi (2,958.67 km) |
