| Gainesville to Storm Lake (Iowa) | 1,144.34 mi (1,841.64 km) |
| Gainesville to Storrs (Connecticut) | 1,009.59 mi (1,624.78 km) |
| Gainesville to Stoughton (Wisconsin) | 991.01 mi (1,594.88 km) |
| Gainesville to Stow (Ohio) | 795.95 mi (1,280.95 km) |
| Gainesville to Streamwood (Illinois) | 912.46 mi (1,468.47 km) |
| Gainesville to Streator (Illinois) | 870.29 mi (1,400.59 km) |
| Gainesville to Streetsboro (Ohio) | 800.63 mi (1,288.49 km) |
| Gainesville to Strongsville (Ohio) | 804.24 mi (1,294.30 km) |
| Gainesville to Stuart (Florida) | 213.93 mi (344.28 km) |
| Gainesville to Stuarts Draft (Virginia) | 606.51 mi (976.09 km) |
| Gainesville to Sturgis (Michigan) | 854.70 mi (1,375.51 km) |
| Gainesville to Suamico (Wisconsin) | 1,079.54 mi (1,737.35 km) |
| Gainesville to Sudley (Virginia) | 687.25 mi (1,106.02 km) |
| Gainesville to Suffern (New York) | 914.13 mi (1,471.15 km) |
| Gainesville to Suffolk (Virginia) | 586.04 mi (943.14 km) |
