| Gainesville to Southern Pines (North Carolina) | 417.66 mi (672.15 km) |
| Gainesville to Southfield (Michigan) | 885.58 mi (1,425.21 km) |
| Gainesville to Southgate (Michigan) | 866.67 mi (1,394.77 km) |
| Gainesville to Southlake (Texas) | 901.78 mi (1,451.27 km) |
| Gainesville to Spanaway (Washington) | 2,444.96 mi (3,934.78 km) |
| Gainesville to Spanish Fork (Utah) | 1,799.05 mi (2,895.30 km) |
| Gainesville to Spanish Lake (Missouri) | 772.39 mi (1,243.04 km) |
| Gainesville to Spanish Springs (Nevada) | 2,212.01 mi (3,559.89 km) |
| Gainesville to Sparks (Nevada) | 2,213.84 mi (3,562.84 km) |
| Gainesville to Spartanburg (South Carolina) | 364.52 mi (586.64 km) |
| Gainesville to Spearfish (South Dakota) | 1,555.71 mi (2,503.68 km) |
| Gainesville to Speedway (Indiana) | 732.83 mi (1,179.38 km) |
| Gainesville to Spencer (Iowa) | 1,168.73 mi (1,880.90 km) |
| Gainesville to Spokane (Washington) | 2,235.08 mi (3,597.02 km) |
| Gainesville to Spokane Valley (Washington) | 2,226.36 mi (3,582.98 km) |
