| Gainesville to Security-Widefield (Colorado) | 1,418.16 mi (2,282.31 km) |
| Gainesville to Sedalia (Missouri) | 879.66 mi (1,415.68 km) |
| Gainesville to Sedro-Woolley (Washington) | 2,463.43 mi (3,964.51 km) |
| Gainesville to Seguin (Texas) | 937.48 mi (1,508.72 km) |
| Gainesville to Selden (New York) | 933.07 mi (1,501.63 km) |
| Gainesville to Selma (Alabama) | 335.70 mi (540.26 km) |
| Gainesville to Selma (California) | 2,194.09 mi (3,531.05 km) |
| Gainesville to Selma (Texas) | 958.20 mi (1,542.07 km) |
| Gainesville to Seminole (Florida) | 129.66 mi (208.67 km) |
| Gainesville to Seven Hills (Ohio) | 809.26 mi (1,302.38 km) |
| Gainesville to Seven Oaks (South Carolina) | 309.87 mi (498.69 km) |
| Gainesville to Severn (Maryland) | 727.96 mi (1,171.54 km) |
| Gainesville to Severna Park (Maryland) | 728.23 mi (1,171.97 km) |
| Gainesville to Sevierville (Tennessee) | 434.67 mi (699.53 km) |
| Gainesville to Seymour (Indiana) | 671.34 mi (1,080.42 km) |
