| Gainesville to Scottsboro (Alabama) | 405.53 mi (652.64 km) |
| Gainesville to Scottsdale (Arizona) | 1,751.46 mi (2,818.70 km) |
| Gainesville to Scranton (Pennsylvania) | 892.17 mi (1,435.80 km) |
| Gainesville to Seabrook (Maryland) | 714.60 mi (1,150.04 km) |
| Gainesville to Seabrook (Texas) | 761.07 mi (1,224.82 km) |
| Gainesville to Seaford (New York) | 907.89 mi (1,461.11 km) |
| Gainesville to Seagoville (Texas) | 863.50 mi (1,389.67 km) |
| Gainesville to Seal Beach (California) | 2,108.00 mi (3,392.50 km) |
| Gainesville to Searcy (Arkansas) | 668.25 mi (1,075.44 km) |
| Gainesville to Seaside (California) | 2,316.48 mi (3,728.01 km) |
| Gainesville to SeaTac (Washington) | 2,445.64 mi (3,935.87 km) |
| Gainesville to Seattle (Washington) | 2,450.10 mi (3,943.06 km) |
| Gainesville to Sebastian (Florida) | 173.07 mi (278.53 km) |
| Gainesville to Sebring (Florida) | 161.59 mi (260.05 km) |
| Gainesville to Secaucus (New Jersey) | 897.10 mi (1,443.75 km) |
