| Gainesville to Enterprise (Nevada) | 1,948.36 mi (3,135.58 km) |
| Gainesville to Enumclaw (Washington) | 2,427.20 mi (3,906.20 km) |
| Gainesville to Ephrata (Pennsylvania) | 804.64 mi (1,294.95 km) |
| Gainesville to Erie (Colorado) | 1,466.13 mi (2,359.50 km) |
| Gainesville to Erie (Pennsylvania) | 868.53 mi (1,397.77 km) |
| Gainesville to Erlanger (Kentucky) | 657.16 mi (1,057.59 km) |
| Gainesville to Escanaba (Michigan) | 1,139.48 mi (1,833.81 km) |
| Gainesville to Escondido (California) | 2,052.34 mi (3,302.92 km) |
| Gainesville to Española (New Mexico) | 1,440.46 mi (2,318.20 km) |
| Gainesville to Essex (Maryland) | 744.45 mi (1,198.08 km) |
| Gainesville to Essex Junction (Vermont) | 1,140.98 mi (1,836.24 km) |
| Gainesville to Estelle (Louisiana) | 465.26 mi (748.77 km) |
| Gainesville to Estero (Florida) | 227.24 mi (365.71 km) |
| Gainesville to Euclid (Ohio) | 824.19 mi (1,326.41 km) |
| Gainesville to Eufaula (Alabama) | 226.79 mi (364.99 km) |
