| Frederick to Orangevale (California) | 2,327.24 mi (3,745.34 km) |
| Frederick to Orchards (Washington) | 2,304.87 mi (3,709.33 km) |
| Frederick to Orcutt (California) | 2,366.88 mi (3,809.12 km) |
| Frederick to Oregon (Ohio) | 351.09 mi (565.02 km) |
| Frederick to Oregon (Wisconsin) | 667.08 mi (1,073.57 km) |
| Frederick to Oregon City (Oregon) | 2,310.30 mi (3,718.07 km) |
| Frederick to Orem (Utah) | 1,807.80 mi (2,909.37 km) |
| Frederick to Orinda (California) | 2,392.66 mi (3,850.61 km) |
| Frederick to Orland Park (Illinois) | 568.52 mi (914.94 km) |
| Frederick to Orlando (Florida) | 789.46 mi (1,270.51 km) |
| Frederick to Ormond Beach (Florida) | 730.98 mi (1,176.39 km) |
| Frederick to Oro Valley (Arizona) | 1,927.22 mi (3,101.56 km) |
| Frederick to Oroville (California) | 2,330.59 mi (3,750.72 km) |
| Frederick to Oshkosh (Wisconsin) | 655.67 mi (1,055.21 km) |
| Frederick to Oskaloosa (Iowa) | 810.74 mi (1,304.75 km) |
