| Frederick to Enterprise (Nevada) | 2,064.95 mi (3,323.21 km) |
| Frederick to Enumclaw (Washington) | 2,271.39 mi (3,655.45 km) |
| Frederick to Ephrata (Pennsylvania) | 83.36 mi (134.15 km) |
| Frederick to Erie (Colorado) | 1,462.50 mi (2,353.67 km) |
| Frederick to Erie (Pennsylvania) | 231.76 mi (372.98 km) |
| Frederick to Erlanger (Kentucky) | 384.92 mi (619.46 km) |
| Frederick to Escanaba (Michigan) | 656.83 mi (1,057.07 km) |
| Frederick to Escondido (California) | 2,232.76 mi (3,593.28 km) |
| Frederick to Española (New Mexico) | 1,577.13 mi (2,538.15 km) |
| Frederick to Essex (Maryland) | 52.56 mi (84.59 km) |
| Frederick to Essex Junction (Vermont) | 413.22 mi (665.01 km) |
| Frederick to Estelle (Louisiana) | 977.51 mi (1,573.15 km) |
| Frederick to Estero (Florida) | 933.52 mi (1,502.35 km) |
| Frederick to Euclid (Ohio) | 262.05 mi (421.72 km) |
| Frederick to Eufaula (Alabama) | 676.75 mi (1,089.12 km) |
