| Frederick to Elyria (Ohio) | 280.92 mi (452.09 km) |
| Frederick to Emeryville (California) | 2,399.47 mi (3,861.58 km) |
| Frederick to Emmaus (Pennsylvania) | 126.82 mi (204.09 km) |
| Frederick to Emporia (Kansas) | 1,010.20 mi (1,625.76 km) |
| Frederick to Encinitas (California) | 2,245.12 mi (3,613.18 km) |
| Frederick to Endicott (New York) | 197.17 mi (317.32 km) |
| Frederick to Endwell (New York) | 199.28 mi (320.70 km) |
| Frederick to Englewood (Colorado) | 1,463.80 mi (2,355.77 km) |
| Frederick to Englewood (Florida) | 906.72 mi (1,459.23 km) |
| Frederick to Englewood (New Jersey) | 207.70 mi (334.27 km) |
| Frederick to Englewood (Ohio) | 367.81 mi (591.94 km) |
| Frederick to Enid (Oklahoma) | 1,131.84 mi (1,821.52 km) |
| Frederick to Ennis (Texas) | 1,179.61 mi (1,898.39 km) |
| Frederick to Ensley (Florida) | 829.78 mi (1,335.39 km) |
| Frederick to Enterprise (Alabama) | 733.65 mi (1,180.70 km) |
