| Frederick to Elkhart (Indiana) | 474.81 mi (764.13 km) |
| Frederick to Elkhorn (Wisconsin) | 620.65 mi (998.84 km) |
| Frederick to Elko (Nevada) | 2,012.04 mi (3,238.07 km) |
| Frederick to Elkridge (Maryland) | 39.52 mi (63.60 km) |
| Frederick to Elkton (Maryland) | 85.75 mi (138.00 km) |
| Frederick to Ellensburg (Washington) | 2,204.26 mi (3,547.42 km) |
| Frederick to Ellicott City (Maryland) | 32.79 mi (52.78 km) |
| Frederick to Elmhurst (Illinois) | 577.03 mi (928.64 km) |
| Frederick to Elmira (New York) | 186.50 mi (300.14 km) |
| Frederick to Elmont (New York) | 214.68 mi (345.50 km) |
| Frederick to Elmwood Park (Illinois) | 571.11 mi (919.12 km) |
| Frederick to Elmwood Park (New Jersey) | 201.42 mi (324.15 km) |
| Frederick to Elon (North Carolina) | 257.06 mi (413.70 km) |
| Frederick to Eloy (Arizona) | 1,951.28 mi (3,140.28 km) |
| Frederick to Elwood (New York) | 236.31 mi (380.30 km) |
