| Frederick to Effingham (Illinois) | 595.66 mi (958.63 km) |
| Frederick to Eggertsville (New York) | 254.59 mi (409.72 km) |
| Frederick to Egypt Lake-Leto (Florida) | 840.89 mi (1,353.29 km) |
| Frederick to El Cajon (California) | 2,235.79 mi (3,598.15 km) |
| Frederick to El Campo (Texas) | 1,283.49 mi (2,065.58 km) |
| Frederick to El Centro (California) | 2,161.44 mi (3,478.51 km) |
| Frederick to El Cerrito (California) | 2,398.32 mi (3,859.73 km) |
| Frederick to El Dorado (Arkansas) | 949.57 mi (1,528.19 km) |
| Frederick to El Dorado (Kansas) | 1,053.54 mi (1,695.51 km) |
| Frederick to El Dorado Hills (California) | 2,318.54 mi (3,731.34 km) |
| Frederick to El Mirage (Arizona) | 1,967.57 mi (3,166.49 km) |
| Frederick to El Monte (California) | 2,259.35 mi (3,636.08 km) |
| Frederick to El Paso (Texas) | 1,702.90 mi (2,740.55 km) |
| Frederick to El Paso de Robles (California) | 2,360.97 mi (3,799.61 km) |
| Frederick to El Reno (Oklahoma) | 1,155.59 mi (1,859.74 km) |
