| Frederick to Eatontown (New Jersey) | 187.69 mi (302.06 km) |
| Frederick to Eau Claire (Wisconsin) | 810.32 mi (1,304.08 km) |
| Frederick to Echelon (New Jersey) | 131.82 mi (212.14 km) |
| Frederick to Eden (North Carolina) | 238.89 mi (384.45 km) |
| Frederick to Eden Prairie (Minnesota) | 901.11 mi (1,450.20 km) |
| Frederick to Edgewater (Florida) | 751.06 mi (1,208.71 km) |
| Frederick to Edgewater (New Jersey) | 205.53 mi (330.77 km) |
| Frederick to Edgewood (Maryland) | 59.66 mi (96.01 km) |
| Frederick to Edgewood (Washington) | 2,285.04 mi (3,677.41 km) |
| Frederick to Edina (Minnesota) | 897.48 mi (1,444.35 km) |
| Frederick to Edinburg (Texas) | 1,500.38 mi (2,414.64 km) |
| Frederick to Edmond (Oklahoma) | 1,123.55 mi (1,808.19 km) |
| Frederick to Edmonds (Washington) | 2,286.43 mi (3,679.66 km) |
| Frederick to Edwards (Colorado) | 1,549.51 mi (2,493.70 km) |
| Frederick to Edwardsville (Illinois) | 674.96 mi (1,086.24 km) |
