| Frederick to Des Plaines (Illinois) | 577.24 mi (928.97 km) |
| Frederick to Desert Hot Springs (California) | 2,183.16 mi (3,513.46 km) |
| Frederick to DeSoto (Texas) | 1,181.88 mi (1,902.06 km) |
| Frederick to Destin (Florida) | 807.31 mi (1,299.24 km) |
| Frederick to Destrehan (Louisiana) | 982.81 mi (1,581.68 km) |
| Frederick to Detroit (Michigan) | 360.10 mi (579.52 km) |
| Frederick to Diamond Bar (California) | 2,249.90 mi (3,620.86 km) |
| Frederick to Diamond Springs (California) | 2,307.32 mi (3,713.27 km) |
| Frederick to Dickinson (North Dakota) | 1,371.27 mi (2,206.85 km) |
| Frederick to Dickinson (Texas) | 1,215.50 mi (1,956.16 km) |
| Frederick to Dickson (Tennessee) | 591.04 mi (951.19 km) |
| Frederick to Difficult Run (Virginia) | 36.94 mi (59.45 km) |
| Frederick to Dinuba (California) | 2,274.32 mi (3,660.17 km) |
| Frederick to Discovery Bay (California) | 2,361.86 mi (3,801.05 km) |
| Frederick to Dix Hills (New York) | 235.23 mi (378.57 km) |
