| Four Corners to Enterprise (Nevada) | 737.84 mi (1,187.44 km) |
| Four Corners to Enumclaw (Washington) | 163.96 mi (263.86 km) |
| Four Corners to Ephrata (Pennsylvania) | 2,370.64 mi (3,815.17 km) |
| Four Corners to Erie (Colorado) | 971.67 mi (1,563.76 km) |
| Four Corners to Erie (Pennsylvania) | 2,132.89 mi (3,432.55 km) |
| Four Corners to Erlanger (Kentucky) | 1,994.42 mi (3,209.71 km) |
| Four Corners to Escanaba (Michigan) | 1,728.95 mi (2,782.48 km) |
| Four Corners to Escondido (California) | 873.66 mi (1,406.02 km) |
| Four Corners to Española (New Mexico) | 1,078.11 mi (1,735.05 km) |
| Four Corners to Essex (Maryland) | 2,382.85 mi (3,834.83 km) |
| Four Corners to Essex Junction (Vermont) | 2,408.88 mi (3,876.72 km) |
| Four Corners to Estelle (Louisiana) | 2,063.28 mi (3,320.54 km) |
| Four Corners to Estero (Florida) | 2,602.98 mi (4,189.09 km) |
| Four Corners to Euclid (Ohio) | 2,075.75 mi (3,340.60 km) |
| Four Corners to Eufaula (Alabama) | 2,211.08 mi (3,558.39 km) |
