| Fort Pierce to Southern Pines (North Carolina) | 539.51 mi (868.26 km) |
| Fort Pierce to Southfield (Michigan) | 1,052.78 mi (1,694.29 km) |
| Fort Pierce to Southgate (Michigan) | 1,033.80 mi (1,663.74 km) |
| Fort Pierce to Southlake (Texas) | 1,072.40 mi (1,725.86 km) |
| Fort Pierce to Spanaway (Washington) | 2,639.32 mi (4,247.57 km) |
| Fort Pierce to Spanish Fork (Utah) | 1,985.76 mi (3,195.77 km) |
| Fort Pierce to Spanish Lake (Missouri) | 969.36 mi (1,560.04 km) |
| Fort Pierce to Spanish Springs (Nevada) | 2,394.68 mi (3,853.87 km) |
| Fort Pierce to Sparks (Nevada) | 2,396.31 mi (3,856.48 km) |
| Fort Pierce to Spartanburg (South Carolina) | 527.82 mi (849.44 km) |
| Fort Pierce to Spearfish (South Dakota) | 1,752.75 mi (2,820.78 km) |
| Fort Pierce to Speedway (Indiana) | 919.05 mi (1,479.07 km) |
| Fort Pierce to Spencer (Iowa) | 1,365.76 mi (2,197.98 km) |
| Fort Pierce to Spokane (Washington) | 2,430.94 mi (3,912.22 km) |
| Fort Pierce to Spokane Valley (Washington) | 2,422.25 mi (3,898.24 km) |
