| Fort Pierce to Silver Firs (Washington) | 2,642.05 mi (4,251.97 km) |
| Fort Pierce to Silver Spring (Maryland) | 822.47 mi (1,323.64 km) |
| Fort Pierce to Silver Springs Shores (Florida) | 154.71 mi (248.99 km) |
| Fort Pierce to Silverdale (Washington) | 2,661.86 mi (4,283.85 km) |
| Fort Pierce to Silverton (Oregon) | 2,619.92 mi (4,216.36 km) |
| Fort Pierce to Simi Valley (California) | 2,312.64 mi (3,721.83 km) |
| Fort Pierce to Simpsonville (South Carolina) | 517.12 mi (832.22 km) |
| Fort Pierce to Sioux City (Iowa) | 1,377.07 mi (2,216.18 km) |
| Fort Pierce to Sioux Falls (South Dakota) | 1,439.98 mi (2,317.43 km) |
| Fort Pierce to Skokie (Illinois) | 1,092.27 mi (1,757.84 km) |
| Fort Pierce to Sleepy Hollow (New York) | 1,013.31 mi (1,630.76 km) |
| Fort Pierce to Slidell (Louisiana) | 604.27 mi (972.47 km) |
| Fort Pierce to Smithfield (North Carolina) | 570.99 mi (918.91 km) |
| Fort Pierce to Smithfield (Utah) | 2,031.55 mi (3,269.46 km) |
| Fort Pierce to Smithville (Missouri) | 1,162.17 mi (1,870.33 km) |
