| Fort Pierce to Olympia Heights (Florida) | 117.56 mi (189.20 km) |
| Fort Pierce to Omaha (Nebraska) | 1,306.22 mi (2,102.16 km) |
| Fort Pierce to On Top of the World Designated Place (Florida) | 165.72 mi (266.71 km) |
| Fort Pierce to Onalaska (Wisconsin) | 1,287.99 mi (2,072.82 km) |
| Fort Pierce to Oneida (New York) | 1,112.70 mi (1,790.71 km) |
| Fort Pierce to Oneonta (New York) | 1,080.00 mi (1,738.09 km) |
| Fort Pierce to Ontario (California) | 2,246.97 mi (3,616.14 km) |
| Fort Pierce to Ontario (Oregon) | 2,326.28 mi (3,743.79 km) |
| Fort Pierce to Opa-locka (Florida) | 105.56 mi (169.89 km) |
| Fort Pierce to Opelika (Alabama) | 470.50 mi (757.19 km) |
| Fort Pierce to Opelousas (Louisiana) | 740.71 mi (1,192.06 km) |
| Fort Pierce to Orange (California) | 2,258.97 mi (3,635.46 km) |
| Fort Pierce to Orange (Texas) | 833.13 mi (1,340.79 km) |
| Fort Pierce to Orange City (Florida) | 119.11 mi (191.69 km) |
| Fort Pierce to Orangeburg (South Carolina) | 420.37 mi (676.52 km) |
