| Fort Madison to Southern Pines (North Carolina) | 750.58 mi (1,207.94 km) |
| Fort Madison to Southfield (Michigan) | 437.35 mi (703.85 km) |
| Fort Madison to Southgate (Michigan) | 435.83 mi (701.40 km) |
| Fort Madison to Southlake (Texas) | 618.95 mi (996.11 km) |
| Fort Madison to Spanaway (Washington) | 1,599.53 mi (2,574.19 km) |
| Fort Madison to Spanish Fork (Utah) | 1,066.35 mi (1,716.12 km) |
| Fort Madison to Spanish Lake (Missouri) | 140.43 mi (225.99 km) |
| Fort Madison to Spanish Springs (Nevada) | 1,490.83 mi (2,399.26 km) |
| Fort Madison to Sparks (Nevada) | 1,494.44 mi (2,405.07 km) |
| Fort Madison to Spartanburg (South Carolina) | 646.47 mi (1,040.40 km) |
| Fort Madison to Spearfish (South Dakota) | 687.52 mi (1,106.46 km) |
| Fort Madison to Speedway (Indiana) | 275.22 mi (442.92 km) |
| Fort Madison to Spencer (Iowa) | 262.10 mi (421.81 km) |
| Fort Madison to Spokane (Washington) | 1,373.74 mi (2,210.82 km) |
| Fort Madison to Spokane Valley (Washington) | 1,364.62 mi (2,196.15 km) |
