| Fleming Island to Southern Pines (North Carolina) | 376.67 mi (606.20 km) |
| Fleming Island to Southfield (Michigan) | 859.51 mi (1,383.24 km) |
| Fleming Island to Southgate (Michigan) | 840.54 mi (1,352.71 km) |
| Fleming Island to Southlake (Texas) | 929.44 mi (1,495.79 km) |
| Fleming Island to Spanaway (Washington) | 2,455.05 mi (3,951.01 km) |
| Fleming Island to Spanish Fork (Utah) | 1,816.68 mi (2,923.66 km) |
| Fleming Island to Spanish Lake (Missouri) | 770.43 mi (1,239.89 km) |
| Fleming Island to Spanish Springs (Nevada) | 2,231.98 mi (3,592.03 km) |
| Fleming Island to Sparks (Nevada) | 2,233.94 mi (3,595.17 km) |
| Fleming Island to Spartanburg (South Carolina) | 335.01 mi (539.15 km) |
| Fleming Island to Spearfish (South Dakota) | 1,560.99 mi (2,512.17 km) |
| Fleming Island to Speedway (Indiana) | 717.14 mi (1,154.13 km) |
| Fleming Island to Spencer (Iowa) | 1,166.61 mi (1,877.48 km) |
| Fleming Island to Spokane (Washington) | 2,242.89 mi (3,609.59 km) |
| Fleming Island to Spokane Valley (Washington) | 2,234.11 mi (3,595.45 km) |
