| Flagstaff to Southern Pines (North Carolina) | 1,810.97 mi (2,914.47 km) |
| Flagstaff to Southfield (Michigan) | 1,598.51 mi (2,572.56 km) |
| Flagstaff to Southgate (Michigan) | 1,598.49 mi (2,572.52 km) |
| Flagstaff to Southlake (Texas) | 841.55 mi (1,354.35 km) |
| Flagstaff to Spanaway (Washington) | 994.54 mi (1,600.55 km) |
| Flagstaff to Spanish Fork (Utah) | 340.14 mi (547.40 km) |
| Flagstaff to Spanish Lake (Missouri) | 1,204.63 mi (1,938.67 km) |
| Flagstaff to Spanish Springs (Nevada) | 538.61 mi (866.81 km) |
| Flagstaff to Sparks (Nevada) | 537.66 mi (865.28 km) |
| Flagstaff to Spartanburg (South Carolina) | 1,673.06 mi (2,692.52 km) |
| Flagstaff to Spearfish (South Dakota) | 763.78 mi (1,229.19 km) |
| Flagstaff to Speedway (Indiana) | 1,421.70 mi (2,288.01 km) |
| Flagstaff to Spencer (Iowa) | 1,036.62 mi (1,668.29 km) |
| Flagstaff to Spokane (Washington) | 912.69 mi (1,468.83 km) |
| Flagstaff to Spokane Valley (Washington) | 909.10 mi (1,463.06 km) |
