| Essex Junction to Southern Pines (North Carolina) | 723.33 mi (1,164.09 km) |
| Essex Junction to Southfield (Michigan) | 526.95 mi (848.04 km) |
| Essex Junction to Southgate (Michigan) | 530.66 mi (854.01 km) |
| Essex Junction to Southlake (Texas) | 1,512.52 mi (2,434.16 km) |
| Essex Junction to Spanaway (Washington) | 2,342.67 mi (3,770.16 km) |
| Essex Junction to Spanish Fork (Utah) | 1,973.31 mi (3,175.74 km) |
| Essex Junction to Spanish Lake (Missouri) | 964.13 mi (1,551.62 km) |
| Essex Junction to Spanish Springs (Nevada) | 2,378.30 mi (3,827.51 km) |
| Essex Junction to Sparks (Nevada) | 2,382.89 mi (3,834.89 km) |
| Essex Junction to Spartanburg (South Carolina) | 807.82 mi (1,300.06 km) |
| Essex Junction to Spearfish (South Dakota) | 1,504.23 mi (2,420.82 km) |
| Essex Junction to Speedway (Indiana) | 745.85 mi (1,200.33 km) |
| Essex Junction to Spencer (Iowa) | 1,099.29 mi (1,769.14 km) |
| Essex Junction to Spokane (Washington) | 2,106.26 mi (3,389.70 km) |
| Essex Junction to Spokane Valley (Washington) | 2,097.25 mi (3,375.19 km) |
