| Esch-sur-Alzette to Sestao | 604.18 mi (972.33 km) |
| Esch-sur-Alzette to Sevilla | 1,035.85 mi (1,667.04 km) |
| Esch-sur-Alzette to Sevilla La Nueva | 798.17 mi (1,284.53 km) |
| Esch-sur-Alzette to Silla | 767.30 mi (1,234.85 km) |
| Esch-sur-Alzette to Silleda | 825.08 mi (1,327.84 km) |
| Esch-sur-Alzette to Sitges | 605.60 mi (974.62 km) |
| Esch-sur-Alzette to Socuellamos | 826.19 mi (1,329.62 km) |
| Esch-sur-Alzette to Soller | 691.19 mi (1,112.37 km) |
| Esch-sur-Alzette to Solsona | 561.00 mi (902.85 km) |
| Esch-sur-Alzette to Son Servera | 694.34 mi (1,117.44 km) |
| Esch-sur-Alzette to Sonseca | 833.25 mi (1,340.99 km) |
| Esch-sur-Alzette to Sopelana | 599.66 mi (965.06 km) |
| Esch-sur-Alzette to Soria | 671.29 mi (1,080.34 km) |
| Esch-sur-Alzette to Suances | 634.17 mi (1,020.61 km) |
| Esch-sur-Alzette to Sueca | 775.55 mi (1,248.13 km) |
