| Erie to Southern Pines (North Carolina) | 479.76 mi (772.10 km) |
| Erie to Southfield (Michigan) | 164.76 mi (265.16 km) |
| Erie to Southgate (Michigan) | 160.54 mi (258.36 km) |
| Erie to Southlake (Texas) | 1,126.31 mi (1,812.62 km) |
| Erie to Spanaway (Washington) | 2,085.24 mi (3,355.88 km) |
| Erie to Spanish Fork (Utah) | 1,639.71 mi (2,638.87 km) |
| Erie to Spanish Lake (Missouri) | 579.85 mi (933.17 km) |
| Erie to Spanish Springs (Nevada) | 2,056.73 mi (3,309.99 km) |
| Erie to Sparks (Nevada) | 2,060.86 mi (3,316.64 km) |
| Erie to Spartanburg (South Carolina) | 505.54 mi (813.59 km) |
| Erie to Spearfish (South Dakota) | 1,200.68 mi (1,932.30 km) |
| Erie to Speedway (Indiana) | 359.85 mi (579.12 km) |
| Erie to Spencer (Iowa) | 768.82 mi (1,237.30 km) |
| Erie to Spokane (Washington) | 1,849.59 mi (2,976.63 km) |
| Erie to Spokane Valley (Washington) | 1,840.37 mi (2,961.79 km) |
