| Enterprise to Southern Pines (North Carolina) | 2,001.93 mi (3,221.79 km) |
| Enterprise to Southfield (Michigan) | 1,756.60 mi (2,826.98 km) |
| Enterprise to Southgate (Michigan) | 1,758.19 mi (2,829.54 km) |
| Enterprise to Southlake (Texas) | 1,049.36 mi (1,688.78 km) |
| Enterprise to Spanaway (Washington) | 850.82 mi (1,369.25 km) |
| Enterprise to Spanish Fork (Utah) | 343.98 mi (553.58 km) |
| Enterprise to Spanish Lake (Missouri) | 1,382.31 mi (2,224.61 km) |
| Enterprise to Spanish Springs (Nevada) | 349.57 mi (562.58 km) |
| Enterprise to Sparks (Nevada) | 347.34 mi (558.99 km) |
| Enterprise to Spartanburg (South Carolina) | 1,866.13 mi (3,003.24 km) |
| Enterprise to Spearfish (South Dakota) | 838.47 mi (1,349.39 km) |
| Enterprise to Speedway (Indiana) | 1,594.28 mi (2,565.75 km) |
| Enterprise to Spencer (Iowa) | 1,173.37 mi (1,888.35 km) |
| Enterprise to Spokane (Washington) | 813.36 mi (1,308.97 km) |
| Enterprise to Spokane Valley (Washington) | 811.70 mi (1,306.31 km) |
