| Enfield Lock to Superior (Colorado) | 4,677.93 mi (7,528.40 km) |
| Enfield Lock to Superior (Wisconsin) | 3,886.49 mi (6,254.70 km) |
| Enfield Lock to Surprise (Arizona) | 5,266.48 mi (8,475.58 km) |
| Enfield Lock to Susanville (California) | 5,142.84 mi (8,276.60 km) |
| Enfield Lock to Sussex (Wisconsin) | 3,910.24 mi (6,292.92 km) |
| Enfield Lock to Suwanee (Georgia) | 4,179.52 mi (6,726.28 km) |
| Enfield Lock to Swansea (Illinois) | 4,194.76 mi (6,750.82 km) |
| Enfield Lock to Sweetwater (Florida) | 4,437.84 mi (7,142.01 km) |
| Enfield Lock to Sweetwater (Texas) | 4,900.40 mi (7,886.44 km) |
| Enfield Lock to Sycamore (Illinois) | 3,980.57 mi (6,406.11 km) |
| Enfield Lock to Sylacauga (Alabama) | 4,311.10 mi (6,938.05 km) |
| Enfield Lock to Sylvania (Ohio) | 3,803.52 mi (6,121.17 km) |
| Enfield Lock to Syosset (New York) | 3,436.84 mi (5,531.06 km) |
| Enfield Lock to Syracuse (New York) | 3,447.62 mi (5,548.41 km) |
| Enfield Lock to Syracuse (Utah) | 4,844.72 mi (7,796.82 km) |
