| Enfield Lock to Storm Lake (Iowa) | 4,189.84 mi (6,742.90 km) |
| Enfield Lock to Storrs (Connecticut) | 3,343.40 mi (5,380.68 km) |
| Enfield Lock to Stoughton (Wisconsin) | 3,957.41 mi (6,368.83 km) |
| Enfield Lock to Stow (Ohio) | 3,738.81 mi (6,017.03 km) |
| Enfield Lock to Streamwood (Illinois) | 3,960.35 mi (6,373.57 km) |
| Enfield Lock to Streator (Illinois) | 4,027.19 mi (6,481.13 km) |
| Enfield Lock to Streetsboro (Ohio) | 3,732.46 mi (6,006.82 km) |
| Enfield Lock to Strongsville (Ohio) | 3,748.25 mi (6,032.23 km) |
| Enfield Lock to Stuart (Florida) | 4,360.67 mi (7,017.83 km) |
| Enfield Lock to Stuarts Draft (Virginia) | 3,786.94 mi (6,094.50 km) |
| Enfield Lock to Sturgis (Michigan) | 3,865.44 mi (6,220.83 km) |
| Enfield Lock to Suamico (Wisconsin) | 3,835.59 mi (6,172.79 km) |
| Enfield Lock to Sudley (Virginia) | 3,689.30 mi (5,937.36 km) |
| Enfield Lock to Suffern (New York) | 3,449.96 mi (5,552.18 km) |
| Enfield Lock to Suffolk (Virginia) | 3,750.12 mi (6,035.23 km) |
