| Enfield Lock to Emeryville (California) | 5,341.48 mi (8,596.28 km) |
| Enfield Lock to Emmaus (Pennsylvania) | 3,530.17 mi (5,681.25 km) |
| Enfield Lock to Emporia (Kansas) | 4,436.51 mi (7,139.88 km) |
| Enfield Lock to Encinitas (California) | 5,462.08 mi (8,790.36 km) |
| Enfield Lock to Endicott (New York) | 3,484.88 mi (5,608.37 km) |
| Enfield Lock to Endwell (New York) | 3,482.32 mi (5,604.25 km) |
| Enfield Lock to Englewood (Colorado) | 4,687.40 mi (7,543.65 km) |
| Enfield Lock to Englewood (Florida) | 4,460.56 mi (7,178.57 km) |
| Enfield Lock to Englewood (New Jersey) | 3,452.74 mi (5,556.65 km) |
| Enfield Lock to Englewood (Ohio) | 3,911.82 mi (6,295.47 km) |
| Enfield Lock to Enid (Oklahoma) | 4,600.33 mi (7,403.52 km) |
| Enfield Lock to Ennis (Texas) | 4,764.15 mi (7,667.16 km) |
| Enfield Lock to Ensley (Florida) | 4,484.61 mi (7,217.29 km) |
| Enfield Lock to Enterprise (Alabama) | 4,386.24 mi (7,058.98 km) |
| Enfield Lock to Enterprise (Nevada) | 5,228.10 mi (8,413.82 km) |
