| Enfield Lock to Elkhorn (Wisconsin) | 3,943.56 mi (6,346.54 km) |
| Enfield Lock to Elko (Nevada) | 4,974.08 mi (8,005.01 km) |
| Enfield Lock to Elkridge (Maryland) | 3,640.34 mi (5,858.56 km) |
| Enfield Lock to Elkton (Maryland) | 3,584.38 mi (5,768.51 km) |
| Enfield Lock to Ellensburg (Washington) | 4,765.25 mi (7,668.93 km) |
| Enfield Lock to Ellicott City (Maryland) | 3,640.32 mi (5,858.53 km) |
| Enfield Lock to Elmhurst (Illinois) | 3,957.25 mi (6,368.57 km) |
| Enfield Lock to Elmira (New York) | 3,514.87 mi (5,656.63 km) |
| Enfield Lock to Elmont (New York) | 3,450.10 mi (5,552.40 km) |
| Enfield Lock to Elmwood Park (Illinois) | 3,951.26 mi (6,358.94 km) |
| Enfield Lock to Elmwood Park (New Jersey) | 3,458.12 mi (5,565.31 km) |
| Enfield Lock to Elon (North Carolina) | 3,895.51 mi (6,269.23 km) |
| Enfield Lock to Eloy (Arizona) | 5,289.38 mi (8,512.44 km) |
| Enfield Lock to Elwood (New York) | 3,428.87 mi (5,518.24 km) |
| Enfield Lock to Elyria (Ohio) | 3,756.17 mi (6,044.97 km) |
